The Emmerdale actress, 35, departed this morning and her fellow housemates have been informed.
A Celebrity Big Brother spokesperson said: “Roxanne has decided to leave the BB House.
“The remaining housemates have been informed”
Roxanne’s dramatic exit comes after she accused Ryan of punching her while they were play fighting.
Footage from Thursday nights’s episode saw the pair in the kitchen where Ryan moved side to side around the soap star throwing mock boxing jabs.
Roxanne said: “That b****y hurt” to which Ryan responded immediately: “Did it? I’m sorry”.
The soap star went to the diary room to complain about the former Coronation Street actor and claimed he punched her in the ribs.
Following her complaint, Big Brother pulled Ryan in for a chat where he was given a formal warning, after which he apologised.
Ofcom have since received more than 11,000 complaints about the incident.
Many viewers took to social media to comment with one person writing: “I’ve reported to Ofcom as wasn’t happy with how Big Brother handled the situation by giving you a warning when evidence showed you did nothing wrong. #cbb."