PUBLISHED: 03:00, Fri, Oct 30, 2020 | UPDATED: 03:47, Fri, Oct 30, 2020
The blaze was reported shortly before 10pm and the cause of the fire is currently unknown.
Three Scottish Fire and Rescue Service crews were deployed to the scene, as well as police officers.
A spokesperson for the SFRS: "We are currently in attendance at a fire at Hairmyres Hospital, East Kilbride.
"We received an alert around 9.45pm and operations control mobilised three appliances.
"Firefighters remain on the scene."
The medical facility has capacity for 492 patients and its A&E ward treats patients from different areas of the county.
Smoke billows from huge blaze in Scotland hospital – ‘terrifying’ (Image: Google Maps)