GETTYMatteo Renzi is in support of the United States of Europe
And the the former prime minister and now democratic candidate said voting for him would allow for him to push his dream of a “United States of Europe”.
Mr Renzi launched his scathing attack on M5S as he urged voters not to back an “extremist government”.
The Five Star party message has resonated with frustrated Italians with its anti-establishment, anti-immigrant message.
Mr Renzi, who is still leader of the Partito Democratico - Democratic Party (PD) - warned Italy was facing the prospect of a government coalition between Five Star and Lega Nord, a rightwing populist party.
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You are not going to vote on Sunday for fantasy football, but for the government of the next five years
The centre-left candidate said: “The risk of an extremist government exists. I do not rule out a government between M5S and Lega, which is why I ask for useful votes, useful votes, useful votes.
“You are not going to vote on Sunday for fantasy football, but for the government of the next five years.
"What will happen after March 5 will be understood only with clear numbers. For me it is essential to see PD first.
"If that is not the case, the Democratic Party is ready to be part of the opposition.”
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GETTYMatteo Salvini is the leader of Lega Nord
The former prime minister is hoping to return to power and was re-elected as the party’s leader under a reformist agenda in April 2017.
In 2016, he resigned from the government with Paolo Gentiloni taking his place.
The PD party is Pro-European and the social integration of immigrants and could potentially decide to form a coalition with the pro-European party