Fans can't say they haven't been warned.
The directors explicitly stated there will be some major casualties and the trailers have given some huge hints.
Express Online readers took a recent poll and voted Iron Man the most likely to die, followed by Captain America, Vision and Loki. All have been shown in extreme danger facing off against Thanos in the trailers, as has Spider-Man.
However, despite Tony Stark's need to always be first, unless there is a major shock it is clear exactly who will be the first to meet his or her maker, or rather, the first to meet Thanos.
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MARVELAvengers Infinity War - who will die first
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Although he is not strictly a hero, this character is a huge fan favourite. His desperate need to belong balanced by his compulsion to reject and destroy trust and love have made Loki irresistible.
Based on the ending of Thor Ragnarok and the scenes shown in the trailers, we fear he could be the character used to set the tone for the rest of the movie and put audiences on the edge of their seats once they realise