Terrified Travelodge guests were forced to fled their hotel at 2am as 100 firefighters battled an inferno on the outside of the five-storey building, which is 'covered in cladding'.
Fifteen fire engines are at the hotel in Brentford, west London, after the blaze started at an adjacent building before spreading to the Travelodge.
Around 160 guests and staff have been evacuated from the building and there are no reports of any injuries.
It comes after pressure group Grenfell United sent a letter to Prime Minister Boris Johnson on Tuesday raising 'grave concerns' that a 'Grenfell-like fire' will occur again.
The letter said: 'It is our conviction that a serious fire in the UK, leading to a loss of life, will occur in a building wrapped in combustible materials unless you act.'
The Travelodge is located less than five miles from the site of the Grenfell Tower disaster, which claimed the lives of 72 people in 2017. Today a London Fire Brigade spokesman said: 'The early indications are that it was not cladding-related.'
Dramatic footage showed flames rising up through a window of the hotel as smoke billowed into the night sky
The hotel is pictured following this morning's blaze in Brentford, west London, which left guests fleeing in terror
Reg Williams, who was staying at the hotel, said parts of the building covered in cladding were 'shrouded' in smoke.
'The fire crews had the hoses in that cladded area for ages,' he said. 'I'm concerned that cladding is still attached to buildings.'
Labour politician Emma Dent-Coad, whose constituency included Grenfell Tower, tweeted: 'While there is breath in my body - in or out of parliament - I will do everything I can to reverse policies that allowed use of combustible materials & ensure unsafe buildings are dealt with asap. This is a national scandal. People will die.'
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Travelodge guests were forced to flee the hotel in the early hours of the morning after an inferno that began in the bins area engulfed the hotel. At least 100 firefighters and 15 fire engines are at the hotel in Brentford, after the blaze started at an adjacent building before spreading to the Travelodge
At least 15 fire engines at the hotel in Brentford, London , after the blaze started in the early hours of the morning which started in a bin room at the rear of the building and spread to hotel
Dramatic footage taken from the scene shows flames sending huge plumes of smoke into the sky
At least 100 firefighters and 15 fire engines are at the hotel in Brentford, west London after the blaze started at an adjacent building before spreading to the Travelodge
Dramatic footage showed flames rising up through a window of the hotel as smoke billowed into the night sky.
Reg Williams, who was staying at the Travelodge, said parts of the building covered in cladding were 'shrouded' in smoke.
'The fire crews had the hoses in that cladded area for ages,' he told the PA news agency.
Mr Williams, from Stratford-Upon-Avon, said the alarm in the hotel went off at 2.45am and the guests were quickly evacuated.
'The fire was quite big, the flames were 20 metres high,' he said. 'It really went up quickly.'
He said that buses were brought in to relocate guests to another Travelodge Hotel in Hounslow but there was not enough room for everyone.
Mr Williams said he was told he would not be able to go back into the hotel until after midday.
'The tiredness is starting to kick in,' he said. 'We've been out in the cold for most of the night.
160 people were evacuated from the five-storey hotel as 100 firefighters fought the blaze which started in the early hours of Wednesday
LFB assistant commissioner Graham Ellis, who was at the scene, said the brigade's control room received 17 calls about the fire
'I'm more concerned about getting back to