Anthony Joshua's reign as world heavyweight champion was ended and a 'Battle of Britain' against Tyson Fury is in tatters after Oleksandr Usyk claimed a stunning unanimous decision win at Tottenham Hotspur Stadium.
Usyk was giving up three inches in height and another one in reach, as well as nearly 20lbs in weight, but the former undisputed world cruiserweight champion's technical acumen came to the fore in an electric atmosphere in London.
As well as giving up several physical advantages to Joshua, Usyk had to contend with the hostile atmosphere that greeted his entrance to the ring from the more than 62,000 that attended this bout.
But he retained an intense focus throughout and his combination of speed and almost non-stop movement from an awkward southpaw stance befuddled Joshua, whose right eye became increasingly swollen as the fight wore on after a succession of rapid left hands found their mark.
Joshua was hurt on several occasions, most notably in the final seconds of the fight as a flurry of punches sent the Briton reeling back to the ropes, just about hanging on from the onslaught before being put out of his misery by the judges.
Joshua finished the bout slumped against the ropes as Usyk looked to seal the fight with a knockout blow. The Ukrainian would later claim his victory was 'nothing special'.
Anthony Joshua's reign as world heavyweight champion was ended at the Tottenham Hotsput Stadium after a stunning upset by Oleksandr Usyk
The Ukrainian would later claim his victory was 'nothing special' after claiming the WBA, IBF and WBO titles after he was given the nod by all three judges
Scores of 117-112, 116-112 and 115-113 were just reward after a stunning set of 12 rounds from unbeaten Usyk, who claimed the WBA, IBF and WBO titles after he was given the nod by all three judges.
Joshua, who was obligated to face WBO mandatory challenger Usyk after a bout against Fury fell through earlier this year, seemed accepting of the result when the scores came as he suffered just the second defeat of his career.
Carl Froch, the former super-middleweight world champion, felt Usyk was well worth his victory.
He told BBC Radio Five Live: 'All the boxing purists who know the game, we always knew Oleksandr Usyk could out-perform AJ, out-box him and beat him on points.
'I don't think any of us knew he could do it in such a manner. Towards the end, he took control, then started to beat him up when he didn't need to.
'That was a boxing match and a proper fight, which in the end Oleksandr Usyk was in control of. He