PUBLISHED: 18:58, Wed, Nov 4, 2020 | UPDATED: 19:00, Wed, Nov 4, 2020
NASA astronauts Shannon Walker, Victor Glover, Michael Hopkins and Japan's Soichi Noguchi will isolate from the world for 14 days. Their quarantine comes amid a recent uptick in COVID-19 infections across the US. America has been the worst-affected country since the coronavirus emerged nearly one year ago, with more than 9.4 million people infected and more than 232,000 dead in the States.
The pandemic has also not escaped the US space agency, which earlier this year implemented a number of measures to stop the virus from spreading.
NASA administrator Jim Bridenstine announced in March America was "fighting an invisible enemy".
He said: "I am grateful to be a part of this tremendous team as we navigate this difficult time together."
But the pandemic has not been entirely disruptive as NASA has achieved several key milestones since the outbreak.
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NASA news: Four astronauts went into quarantine before SpaceX's Crew-1 launch (Image: SPACEX)
NASA news: The SpaceX Crew Dragon docked to the ISS (Image: NASA)
On July 30, NASA and United Launch Alliance (ULA) launched the Mars Perseverance rover towards Mars on a bold mission to search for signs of life.
And just two months before that, NASA astronauts Bob Behnken and Doug Hurley flew on the first crewed SpaceX Crew Dragon flight to the space station.
The mission demonstrated SpaceX's capabilities and marked the first launch of American astronauts from US soil since the Space Shuttle retired in 2011.
But the flight was a safety demonstration and the first operational flight - Crew-1 - is pencilled in to blast off on November 14.
The launch will come at the end of the four astronauts' mandatory quarantine, which began on October 31.
NASA said: "For crews preparing to launch, 'flight crew