The 68-year-old reality star, previously known as Bruce, vented her anger at the presenter, 52, after she took offence to a question he asked about her changed body parts since transitioning to a woman in 2016.
The outspoken host held a male doll of Caitlyn resembling her time as Bruce, an Olympic gold medal-winning decathlete.
Pointing at the doll, Piers asked her: “How does your physique now compare to what it was like then? Obviously certain areas we know…"
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Caitlyn Jenner poses in a long, flowing pink dress
This is serious stuff, people die over this issue, it is not a joke
A distressed Caitlyn interrupted and said: “See you made a comment there and that’s why you would get in trouble, ok?”
A shocked Piers pulled a puzzled face back at the star before Caitlyn