The stars were out in force for The Room Next Door premiere held at the 81st annual Venice Film Festival in Italy on Monday night.
Leading lady Julianne Moore was the epitome of glamour in a dazzling gold sequin dress as she took to the red carpet at the Venice Lido.
The actress, 63, turned heads in the impeccable garment that featured a plunging neckline and was teamed with towering silver heels, while she pulled her red tresses back.
Meanwhile her co-star Tilda, also 63, opted for a very different look - wearing a quirky light grey jacket, matching trousers and heels.
The Room Next Door follows war correspondent Martha, played by Tilda, and her difficult relationship with her daughter and childhood friend Ingrid, Julianne, who she reconnects with after losing touch for many years.
It marks the English-language debut feature from two-time Oscar winner Pedro Almodóvar, who's helmed 22 prior Spanish-language feature films throughout his illustrious 44-year career.
Almodóvar joined his two leading ladies on the red carpet wearing an eye-catching light pink suit and looked in great spirits.
The Oscar-winning actresses portray best friends Martha, a war correspondent, and Ingrid, an author, in the movie which began production on March 3 in Madrid.
Actress Taylor Russell, 30, also posed at the premiere wearing a white crop top and matching puffy skirt as she continued her red carpet parade at the festival.
Tilda previously starred in 74-year-old Almodovar's 2020 short film The Human Voice, and she gushed that they 'really love each other.'
'We are really enjoying ourselves,' Tilda gushed to IndieWire in February.
'It's really thrilling. For me, as just a film fan, I'm just so thrilled for all of us that Pedro is making another movie, and it's going to be a real Pedro movie.'
Swinton continued: 'It's a beautiful thing, and I can't say that much more about it, but I can tell you it's a real Almodóvar film.
'What I can tell you is that it's about mature friendship in a way...It's about mature friendships and how they sustain us and what we need them for at this stage in our lives. So it's going to be meaty.'
The Room Next Door - also starring John Turturro and Alessandro Nivola - has already received a North American distribution deal with Sony Pictures Classics.
Julianne worked the red carpet without her film director husband Bart Freundlich.
The couple actually met when the actress was hired to star in his drama film The Myth Of Fingerprints in 1996, and soon after the production began they both could sense an attraction.
The pair began dating, essentially setting up a long and loving romance that still going to this day.
Moore would also star in Freundlich's next feature film, the drama World Traveler, and again in the romantic comedy-drama Trust The Man and the drama After The Wedding.
Waisting little time in starting up a family, they welcomed their son Caleb, now 26, the following year.
Moore and Freundlich would grow their family again with the arrival of daughter Liv, 22, in April 2002.
Ultimately, the pair decided to make their union legal and get married just over a year later, in August 2003.
With their son now on his own after graduating from college and her daughter set to graduate soon, the couple have been empty nesters for a few years. But still, they both have been grateful to have had the careers they do while raising their children.
'We're really lucky because of what we do; our lives are so, so flexible,' she told Harper's Bazaar. 'We have a very solid family life and it is the most satisfying thing I have ever done.'
Most recently, Moore stars in the leading lady role of Mary Villiers, Countess of Buckingham, in the miniseries Mary & George that airs on Starz in the U.S.
The actress has two new films now in post production: the thriller Echo Valley with Sydney Sweeney and Domhnall Gleeson and Almodóvar's The Room Next Door.