Lottie Moss was rushed to hospital after she took high doses of Ozempic given to her by a friend who bought it under the counter from a doctor.
The model, 26, was violently ill, suffering a seizure and severe dehydration after taking the drug when she weighed around 60kg - just 9stone.
She said she would rather 'die' than use Ozempic again, which is meant to treat the obese or diabetics and has suffered global shortages.
Her sister is supermodel Kate Moss, 50, who was poster girl for 'heroin chic' in the 1990s due to her slim frame and once famously declared, 'nothing tastes as good as skinny feels.'
Lottie recalled having the seizure, which was caused by severe dehydration, and said her face and hands clenching up was one of the 'scariest' experiences she has ever endured.
She said there were, 'small things I wish I'd known before taking it' and revealed her weight plummeted to around 53kg in a few weeks.
After being seen by medical professionals, Lottie learned the dosage of Ozempic she was injecting into her leg should be prescribed to someone weighing at least 100 kilos - nearly double her size.
Lottie explained: 'A few months ago, I was not feeling happy about my weight, I had a friend, and she could get it for me.
'It was below board, from a doctor, but it wasn't like you go into a doctor's office and he prescribes it for you, takes your blood pressure, and takes tests, which is what you need when you go on something like Ozempic.
'At the end of the day it is a medication, it is dangerous and really meant for weight loss of people of a very large size.
'When I was taking it, the amount that I was taking was meant for people who are 100 kilos and over and I'm in the 50s range.
'It's these small things I wish I'd known before taking it. But I took it, you inject it into your leg, and it was the worst decision I ever made.
'This is a warning to everyone. Please, if you're thinking of taking it, do not take it, it's so not worth it.'
The OnlyFans star described the severe side effects she suffered as a result of taking the drug such as vomiting, losing the colour in her face, and dramatically dropping in weight.
Speaking on her podcast Dream On, Lottie said she weighed approximately 60 kilos before she dropped to 57 following her first dose and was 53 kilos at her lowest, which is just over eight stone.
She said: 'I would rather die any day than take it again. It made me feel so nauseous.
'I took it for two weeks. It comes with a pen and different doses, you take one injection one week, one injection the next week and you take every week, and I've never felt sicker in my life.
'I was throwing up, it was horrible. I took a lower dosage the first time I took it then I went up higher. I ended up being in bed for two days, felt so sick, my weight had dropped.
'I started at about 60 kilos, and I went down to 57 with the first dose, then I went down to 54.
'It was crazy, my lowest was 53. In terms of a few weeks, that's not a healthy weightloss, not a healthy drop.
'When I was in bed for those two days and it was at the end of it and I just wanted to come off it, because it's not like you can stopping taking it, it's not like a pill that you don't take when you wake up in the morning, it's in your system and it's there.
'I felt so sick one day I said to my friend, "I can't keep any water down, I can't keep any food down, no liquids, nothing. I need to go to hospital, I feel really sick."'
After she was rushed to A&E, Lottie had a seizure due to her dehydration, recalling the 'horrible' experience which saw her close friend hold down her feet as she contorted on the hospital floor.
The former Celebs Go Dating star said the nurse who treated her was shocked to learn the high dosage she had been taking and the amount of weight she lost during a short period.
She said: 'We went to ER at three in the morning, we go and see one of the nurses and she's like "how much of a dose are you taking?" I was like however much and she was like "oh my god, that's so not the amount you should be taking." She asked how much weight I'd lost in two weeks and I told her….
'She sent me to the emergency room, and I got wheelchaired through the hospital.
'At one point, I went to the bathroom, and I felt really sick, I felt like I was going to pass out, I thought something was happening, I didn't feel good.
'As soon as I got into the room where I was seen by another nurse, I literally had a seizure from how dehydrated I was, which was honestly one of the scariest things that has ever happened to me in my life.
'My friend Reece had to hold my feet down and it was just so scary, the whole situation, I didn't know what was going on, my face was clenching up, my whole body was tense, my hands, it was so weird, your hands clench up and you can't move them and it feels like you're going to break your hand. It was honestly horrible.'
Lottie has spoken in the past about growing up in the 'toxic' fashion industry and the time she spent in rehab following drug addiction.
She started modelling aged 16 after being scouted when she was 13 and said she always felt like she was living in sister Kate's shadow.
The star admits she was ridiculed for eating on set during fashion shoots and was told by her modelling agency she wouldn't have a chance at walking in runway shows unless she had a 23-inch waist.
Overhearing remarks about her body and being branded the 'ham and cheese sandwich girl' on set was 'traumatising' for Lottie, who says she feels 'lucky' not to have developed an eating disorder.
In her 90s heyday, Kate became the poster girl for 'heroin chic' due to her slim figure and her phrase 'nothing tastes as good as skinny feels', which she now regrets.
During a new Disney+ documentary, Kate has revealed the abuse she faced for her 'skinny' aesthetic, explaining: 'Parents would come up to me and say, "My daughter's anorexic." It was awful.'
But now Lottie has said following the rise of Ozempic, which has been popularised by celebrities, 'heroin chic' is making an alarming comeback, which needs to be stopped in its tracks.
Lottie said: 'I hope by me talking about this and saying my experience with it can be a lesson to some people, it's so not worth it.
'It's for diabetes, it's not for weight loss really. I get that in the media everyone and all these celebrities are on it right now and it's so hard to look at that and see these dramatic weight losses, especially for people with eating disorders and problems with eating, it's so hard to see that when maybe you're not someone who drops weight quickly or you're struggling with recovering.
'This heroin chic trend right now coming back, which is something that happened in the 90s, we should not be going back there.
'This should not be a trend right now... Where did the body positivity go? I don't understand because we were doing so well, the curvy girls were eating and it was becoming more of a trend to be curvier and sexy and now it's gone back in time to this heroin chic, not eating, being super, super thin.
'And obviously if that's your body type and you are naturally very thin then this excludes you but just be happy with your weight and happy you have a body that functions and works instead of putting it through something like that. It can be so detrimental to your body in the future.'