The 4.5-magnitude quake hit the tourist hotspot at 8:57pm local time (7:57pm UK time) last night, according to Italian authorities.
Two women died and 39 people are injured – at least one of them seriously – after the earthquake struck.
Seven are still missing as officials rush to find them in the rubble.
One woman died after the island's historic church collapsed, while the other woman was buried under the rubble of her home in the town of Casamicciola, some 3km (2 miles) north of the epicentre.Related articles
GETTYIschia in Italy has been struck by a deadly earthquake which has killed two people
All doctors and patients were evacuated from the Rizzoli Hospital during the disaster, local media outlets have reported.
Aftershocks were felt as rescue teams worked through the night, pulling alive a seven-month-old baby from a collapsed home.
Locals and tourists ran out onto the street as the earthquake triggered a short electrical blackout across the island.
Ischia is a volcanic island off the coast of Naples and south of Rome.
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Italian Carabinieri police officer and a doctor carry a child after an earthquake hit the island of Ischia, off the coast of Naples
GETTYIschia: The 4.5-magnitude earthquake struck the Italian tourist spot last night
It’s popular with holidaymakers for its beaches and thermal waters.
The Foreign and Commonwealth Office (FCO) is yet to update its travel advice, but does warn of the threat from earthquakes and volcano eruptions throughout Italy.