They fell out as a byproduct of their husband's feud.
E! reported that the duo came face-to-face for the first time since the rappers' fall out.
Witnesses claimed the pair were at the VIP bar together, toasting the bride and groom with champagne.
The Instagram queens used to be close, something not all Bey's fan were always impressed by.
Beyonce was also a no show at Kim and Kanye's wedding, despite her and husband Jay Z's names being engraved into a marble table waiting for them there.
The feud was made official when Kanye ranted about Jay Z during a concert last year, claiming their kids never even played together, and accusing Beyonce of refusing to perform at the VMAs unless her video beat his.
Out: Beyonce was spotted leaving New Orleans on Friday
Head down: Bey did her very best to keep a low profile
mended? E! reported she and Kim came face-to-face at the ceremony
Hidden: Beyonce was just as shy on her arrival on Thursday
Ghosting: She even hid behind a sheet as she was driven away from the venue on Thursday night
Jay Z was enraged his family was dragged into it, hitting back at Kanye in a number of interviews, and even calling him out by name on his latest album.
But the nuptials of friend in common Williams to Reddit founder Alexis Ohanian was an an opportunity for the former friends to patch things up.
Neither Kanye nor Jay Z accompanied their wives to the ceremony.
En route: Kim was spottedarriving at the Contemporary Arts Center in New Orleans for Serena Williams and Alexis Ohanian's wedding
The platinum haired Beauty was busy on her phone as her car pulled up at the venue for the tennis star's nuptials
Never not entrancing: Kim Kardashian (above) exits the airport after touching down in New Orleans on Thursday
Bey and Kim were just two of the plethora of stars who traveled to new Orleans for the wedding, along with Serena's sister Venus, and her two-month-old daughter Alexis Olympia Ohanian Jr.
The members of New Edition, who played a five-song set during the reception, were spotted arriving at the Contemporary Arts Center for the Beauty and the Beast themed bash.
Guests were also gifted one of Williams' unique golden trophy party favors. Each guest table at the event had been named after one of Williams' 12 grand slam titles, and her favors were recreations of the trophies she received for each corresponding title.
Happier times: The Instagram queens used to be close, something not all Bey's fan were always impressed by (pictured February 2015)
Family feud: They fell out proper as a byproduct of their husband's feud
Jay-Z's mother Gloria was seen as she climbed off a plane alongside Beyonce.
Editor-in-chief of Vogue Anna Wintour was seen arriving at the event, with her magazine having an exclusive on the images. Cellphones are reportedly banned from the ceremony.
She was later spotted at the bar for the cocktail reception in a closed-off street outside the Contemporary Arts Center.
Baby, baby: Alexis Olympia Ohanian Jr. heads home after her parents wedding (above)
Anna Wintour hits the bar at the cocktail reception in a closed-off street outside the Contemporary Arts Center
Wintour enjoyed a non-alcoholic beverage during the mini street party for the wedding guests
Anna Wintour and guests enjoy a street party with a New Orleans band at Serena Williams' wedding
The Vogue editor was spotted chatting with guests, and with a staff member at the reception
The Knowles family arrived together at the venue's VIP entrance. Pictured are Beyonce's mom Tiny (backseat, right) and her new husband actor Richard Lawson (backseat, left)
Tina Knowles looked glamorous in red lipstick and curled blonde hair, while her husband Richard sat next to her
Guests enjoy a cocktail reception in a closed-off street outside the Contemporary Arts Center in New Orleans
Guests, who were told to dress in keeping with the Beauty and the Beast theme, were greeted with the Disney movie's famous song Be Our Guest and offered welcome drinks, a source told ET.
Outside the venue, guests enjoyed a cocktail or champagne on a street closed off to the public. Incongruous with the lavish affair, sources at the scene said that the venue had provided a 'strange porta potty.'
DailyMail.com got photos of original New Edition members Ricky Bell, Michael Bivins, Ronnie DeVoe, Johnny Gill and Ralph Tresvant on Thursday.
Bobby Brown will not be attending per a source and when asked for details about the performance, Bivins shouted: 'Got a gag order.'
Couple Eva Longoria and Jose Bastion were seen entering Serena Williams and Alexis Ohanian wedding in New Orleans
Housewife: Eva Longoria and her husband Jose Baston were seen at the big celebrity bash
Ciara (left) and La La Anthony (right) are two of Serena's closest friends and both attended her bachelorette party
Singer-songwriter Ciara Princess Harris, known mononymously as Ciara, arrived at the venue for the wedding
Model Selita Ebanks flashed a winning smile for the cameras as she arrived for the wedding in a purple chiffon number
The blonde Beauty wore a sheer blue dress with glittery detailing, while Haynes wore a suit with velvet trim
Legendary Vogue editor Anna Wintour arrived, wearing her signature dark shades and statement jewelry
The group will be just one of the many musical acts on hand for the big night. A brass band was also spotted serenading guests at the cocktails reception.
A source said that Serena wore not one, but two dresses for the occasion, one for the ceremony and one for the reception which was due to last until 3am.
DeWayne Crocker Jr., 21, a Pensacola singer who’s a rising star of gospel, was due to perform while backed up by a New Orleans groups called Restored.
New Orleans funk/jazz band Naughty Professor were also booked to play and the traditional marching brass band Paulin Brothers Brass Band were also due to be in attendance to entertain guests.
Patrick Mouratoglou, who has been Serena's coach since 2012, posted this image of her alongside her now-husband Alexis Ohanian on Instagram, along with his best wishes for her special day